Komodo blood found to have 'superantibacterial' properties
- Komodo dragons have at least 57 types of bacteria in saliva, but appear resistant
- Researchers incubated Komodo dragon blood, revealing antimicrobial activity
- Discovery could help develop new drugs to fight antibiotic-resistant superbugs
By
Cheyenne Macdonald For Dailymail.com
Published: 22 February 2017
They’re the largest lizards in the world, with deadly saliva that’s loaded with
at least 57 species of bacteria to bring down their prey.
And,
according to new research, the blood of Komodo dragons could be the key
to developing new drugs in the fight against antibiotic-resistant
superbugs.
The team used a method known
as ‘bioprospecting,’ revealing antimicrobial protein fragments in their
blood that protects them against infections.
They’re the largest lizards in the
world, with deadly saliva that’s loaded with at least 57 species of
bacteria to bring down their prey. And, according to new research, the
blood of Komodo dragons could be the key to developing new drugs to
fight antibiotic-resistant superbugs
THE GROWING THREAT OF SUPERBUGS
Antibiotic
resistance occurs when bacteria change to 'outsmart' or resist
antibiotic medicine, making it close to impossible to treat the
infection.
The bacterium that carries resistance genes to many different antibiotics is called a superbug.
Most of these infections occur in hospitals or in medical care facilities, such as nursing homes.
The
Centers for Disease Control and Prevention said that more than two
million people are infected with antibiotic resistant bacteria every
year.
More than 23,000 people die from these infections each year.
Experts say that if the epidemic is not brought under control, superbugs may kill more people than cancer by the year 2050.
In
the study, researchers from the College of Science at George Mason
University investigated whether they could isolate substances known as
cationic antimicrobial peptides from Komodo dragon blood – massive
lizards the dwell on five small islands in Indonesia.
These
CAMP substances are an essential part of the innate immune system, and
the team had previously done this with alligator blood.
In
a technique called bioprospecting, they incubated the Komodo dragon
blood with negatively charged hydrogel particles that they developed to
capture the positively charged peptides.
This allowed the researchers to identify and sequence 48 potential CAMPS with mass spectrometry.
All of these, except for one, was derived from histone proteins.
These types of proteins are known to have antimicrobial activities.
The researchers then synthesized eight and tested them against Pseudomonas aeruginosa and Staphylococcus aureus.
The antibiotic resistant strain of S. Aureus (MRSA) is a growing problem worldwide.
The analysis revealed that seven of the peptides from the Komodo dragon blood were potent against both of the bacteria.
The eighth peptide was only effective against P. aeruginosa.
The researchers then synthesized eight
and tested them against Pseudomonas aeruginosa and Staphylococcus
aureus. The antibiotic resistant strain of S. Aureus (MRSA) is a growing
problem worldwide
It’s thought that the bacteria in Komodo dragons’ saliva helps them to kill their prey.
But, the dragons themselves appear to be resistant.
According to the new research, serum derived from the animals may have antibacterial abilities as well.
This could pave the way for new therapeutics to treat antibiotic resistant bacteria.
‘The
study demonstrates the power and promise of our bioprospecting approach
to cationic antimicrobial peptide (CAMP) discovery and it reveals the
presence of a plethora of novel h
‘These
findings may have broader implications regarding the role that intact
histones and histone-derived peptides play in defending the host from
infection.’